Phenotypes Associated with This Genotype

Genotype
MGI:5755101

cn17

• Allelic Composition: Nras^tm1Tyj/Nras⁺; Tg(Tyr-cre)1Lru/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavior ( J:198244 )

• progress to akathisia and general malaise

hyperresponsive to tactile stimuli ( J:198244 )

• at a median age of 12.5 months

tremors ( J:198244 )

• seen at a median age of 12.5 months

impaired coordination ( J:198244 )

• mice exhibit incoordination at a median age of 12.5 months

abnormal gait ( J:198244 )

• mice show impaired gait at a median age of 12.5 months

skeleton

abnormal cranium morphology ( J:198244 )

• most mice develop increasing cranial perimeter or cranial deformity symptoms

mortality/aging

premature death ( J:198244 )

• mice begin to die around 6 months of age with about 25% surviving past 18 months of age

craniofacial

abnormal cranium morphology ( J:198244 )

• most mice develop increasing cranial perimeter or cranial deformity symptoms

pigmentation

hyperpigmentation ( J:198244 )

• darkening of the skin, tails, paws, and snouts that is evident from day 1 and persists throughout life, that is less pronounced than that in homozygotes