Phenotypes Associated with This Genotype

Genotype
MGI:5755966

• Allelic Composition: Tg(Alb-HBx)A112Tfts/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased hepatocellular carcinoma incidence ( J:104728 )

♂ • 100% incidence of hepatocellular carcinoma in males by 17-18 months of age, with carcinoma first appearing at around 13-14 months of age

♂ • fibrosis, bizarre nuclei, cytoplasmic lipid droplets, necrosis, inflammation, and mitosis are frequently seen within the hepatocellular carcinoma

♂ • hyaline globules are occasionally seen in some hepatocellular carcinoma samples

liver/biliary system

abnormal liver morphology ( J:104728 )

♂ • multifocal areas of altered hepatocytes and dysplasia with mild to moderate pleomorphic nuclei in the liver

liver hyperplasia ( J:104728 )

♂ • hyperplastic nodules in the liver, resembling liver adenomas, are seen at 12 months of age

hepatic steatosis ( J:104728 )

♂ • presence of cytoplasmic vacuoles indicative of hepatic steatosis are seen at 6-12 months of age

increased hepatocellular carcinoma incidence ( J:104728 )

♂ • 100% incidence of hepatocellular carcinoma in males by 17-18 months of age, with carcinoma first appearing at around 13-14 months of age

♂ • fibrosis, bizarre nuclei, cytoplasmic lipid droplets, necrosis, inflammation, and mitosis are frequently seen within the hepatocellular carcinoma

♂ • hyaline globules are occasionally seen in some hepatocellular carcinoma samples

impaired liver regeneration ( J:104728 )

♂ • mice show an increase in mortality post-hepatectomy, with about 70% of mice dying within 72 hours after hepatectomy

♂ • impaired liver regeneration after hepatectomy, with the rate and amount of liver mass restoration lower than in wild-type controls

♂ • while an increase in regenerated liver mass is seen, albeit at a lower level, no increase in hepatocyte cell number is seen; this increase is due to fat accumulation in hepatocytes

♂ • increase in liver damage post-hepatectomy compared to wild-type controls

♂ • post-hepatectomy, hepatocytes show impaired DNA synthesis response and mitosis, prolonged immediate-early gene induction and impaired activation of the G1, S, and G2/M phase markers

♂ • regenerating livers post-hepatectomy show increased necrosis and apoptosis, steatosis, and impaired glycogen storage

homeostasis/metabolism

increased circulating alanine transaminase level ( J:104728 )

♂ • increase in serum ALT levels after formation of hepatocellular carcinoma

growth/size/body

liver hyperplasia ( J:104728 )

♂ • hyperplastic nodules in the liver, resembling liver adenomas, are seen at 12 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:104728