Phenotypes Associated with This Genotype

Genotype
MGI:5756630

• Allelic Composition: Minar2^{tm1b(KOMP)Wtsi}/Minar2^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Minar2^{tm1b(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0770_5_F06

Data Sources

IMPC Data for Minar2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased total body fat amount ( J:211773 )

IMPC - WTSI

behavior/neurological

decreased exploration in new environment ( J:298983 )

• mice are slower to engage in exploratory behavior in a new environment

absent pinna reflex ( J:211773 )

IMPC - WTSI

limb grasping ( J:298983 )

• mice show delayed hind-limb reflex

• mice are unable to display hind-limb clasping

impaired coordination ( J:298983 )

• mice take longer to turn and descend the pole than wild-type mice in the pole test, with mice showing difficulty in orienting downwards completely

• mice show more foot slips than wild-type mice in traversing the balance beam

decreased grip strength ( J:298983 )

• mice struggle to maintain grip and frequently fail to remain on the bar on a horizontal bar and show reduced grip strength

abnormal gait ( J:298983 )

• mice exhibit abnormal gait, meandering from side to side through the walkway mice have a greater average distance between ipsilateral fore and hind paw prints and greater variation in stride width, indicating that mice walk with more irregular, less uniform step alterations compared to wild-type mice

decreased vertical activity ( J:298983 )

• mice show less rearing in a new environment; mice attempt to rear by standing in hind limbs but misjudge the distance by standing too far away from the wall or only rest one forelimb on the wall indicating impaired rearing ability

bradykinesia ( J:298983 )

• some mice present with bradykinesia-like symptoms which is more prominent in older mice

growth/size/body

decreased lean body mass ( J:211773 )

IMPC - WTSI

decreased body length ( J:211773 )

♂

IMPC - WTSI

hearing/vestibular/ear

abnormal auditory brainstem response ( J:211773 )

IMPC - WTSI

homeostasis/metabolism

decreased circulating glucose level ( J:211773 )

IMPC - WTSI

decreased circulating phosphate level ( J:211773 )

IMPC - WTSI

nervous system

loss of dopaminergic neurons ( J:298983 )

• loss of TH+ cells in the substantia nigra pars compacta

skeleton

abnormal bone structure ( J:211773 )

♀

IMPC - WTSI

decreased bone mineral content ( J:211773 )

IMPC - WTSI

decreased bone mineral density ( J:211773 )

IMPC - WTSI

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease		DOID:14330	OMIM:PS168600	J:298983