Phenotypes Associated with This Genotype

Genotype
MGI:5762620

• Allelic Composition: Tg(S100b-v-erbB)4496Waw/0; Trp53^tm1Brd/Trp53^tm1Brd
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased glioma incidence ( J:225862 )

• marker analysis indicates that oligodendroglial progenitor cell-derived high grade glioma has proneural character

• in vivo radiation of the high grade glioma induces proneural-to-mesenchymal transition, increasing invasiveness and malignancy

• irradiated proneural high grade glioma cells undergoing proneural-to-mesenchymal transition show increased invasiveness and resistance to temozolomide treatment

increased oligodendroglioma incidence ( J:225862 )

nervous system

increased glioma incidence ( J:225862 )

• marker analysis indicates that oligodendroglial progenitor cell-derived high grade glioma has proneural character

• in vivo radiation of the high grade glioma induces proneural-to-mesenchymal transition, increasing invasiveness and malignancy

• irradiated proneural high grade glioma cells undergoing proneural-to-mesenchymal transition show increased invasiveness and resistance to temozolomide treatment

increased oligodendroglioma incidence ( J:225862 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
high grade glioma		DOID:3070	OMIM:PS137800	J:137800