Phenotypes Associated with This Genotype

Genotype
MGI:5762957

• Allelic Composition: Ywhaz^{Gt(OST432062)Lex}/Ywhaz^{Gt(OST432062)Lex}
• Genetic Background: either: B6.129S5-Ywhaz^{Gt(OST432062)Lex} or C.129S5-Ywhaz^{Gt(OST432062)Lex} or (involves: 129S5/SvEvBrd * 129T2/SvEmsWehi))

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:217297 )

• some mice die by P21

• however, mice that survive exhibit normal life expectancy

nervous system

nervous system phenotype ( J:217297 )

N • mice exhibit normal prefrontal cortex, cingulate cortex, amygdala, thalamus, nucleus accumbens, motor cortex and neuronal viability

abnormal neuronal migration ( J:217297 )

• failure of neurons to migrate from their birthplace or to stop within their correct layer

abnormal hippocampal mossy fiber morphology ( J:217297 )

• infrapyramidal mossy fibre tract are misrouted amongst the CA3 neurons compared to in wild-type mice

• misrouted axons form aberrant synapses within the stratum pyramidale

abnormal hippocampus layer morphology ( J:217297 )

• disrupted organization

abnormal hippocampus granule cell morphology ( J:217297 )

• diffusely packed

abnormal hippocampus pyramidal cell layer ( J:217297 )

• split in to a bilaminar stratum

ectopic hippocampus pyramidal cells ( J:217297 )

• in the stratum radiatum and stratum oriens

• in the superficial layer of CA3

abnormal dendrite morphology ( J:217297 )

• pyramidal neurons exhibit dendrites with thorny excrescences from the misrouted mossy fibre tracts on both proximal and distal apical dendrites compared with wild-type cells

• however, the number of branch points is normal

decreased prepulse inhibition ( J:217297 )

behavior/neurological

behavior/neurological phenotype ( J:217297 )

N • mice exhibit normal sensorimotor abilities (olfaction, vision, balance and self-righting, eye blink, ear twitch, whisker-orientation and neuromuscular strength) and rearing

impaired long-term object recognition memory ( J:217297 )

• impaired

abnormal spatial working memory ( J:217297 )

• in a cross-maze, mice exhibit increased latency in reaching the escape platform over the course of the acquisition period, decreased arm choice accuracy and increased escape latency compared with wild-type mice

decreased anxiety-related response ( J:217297 )

• in an elevated plus maze, mice spend more time in open arms and enter them more often with increased head dips and fewer stretched attend postures compared with wild-type mice

abnormal response to novel object ( J:217297 )

• impaired novel object recognition when presented with a familiar and new object

• hyperactivity in the object recognition test with longer exploration time in both phases of the trial

decreased startle reflex ( J:217297 )

increased locomotor activity ( J:217297 )

• increased distance traveled in an open field in male and female mice

• hyperactivity in the object recognition test with longer exploration time in both phases of the trial

• increased activity in an elevated plus maze

growth/size/body

decreased body size ( J:217297 )

• from P14 onward

postnatal growth retardation ( J:217297 )

• at P14

cellular

abnormal neuronal migration ( J:217297 )

• failure of neurons to migrate from their birthplace or to stop within their correct layer

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:217297