Phenotypes Associated with This Genotype

Genotype
MGI:5763076

• Allelic Composition: Tg(MMTV-ENPP2)20Gbm/0
• Genetic Background: FVB/N-Tg(MMTV-ENPP2)20Gbm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal mammary gland morphology ( J:149661 )

♀ • mammary glands from virgin females show a slight increase in side branching

increased mammary adenocarcinoma incidence ( J:149661 )

♀ • 13 of 21 multiparous females develop mammary carcinomas

♀ • females show varying frequencies of mammary gland hyperplasia, mammary intraepithelial neoplasia, invasive mammary carcinoma and metastasis to other organs

increased mammary gland tumor incidence in breeding females ( J:149661 )

♀ • multiparous, but not virgin, females develop mammary gland carcinomas

integument

abnormal mammary gland morphology ( J:149661 )

♀ • mammary glands from virgin females show a slight increase in side branching

increased mammary adenocarcinoma incidence ( J:149661 )

♀ • 13 of 21 multiparous females develop mammary carcinomas

♀ • females show varying frequencies of mammary gland hyperplasia, mammary intraepithelial neoplasia, invasive mammary carcinoma and metastasis to other organs

increased mammary gland tumor incidence in breeding females ( J:149661 )

♀ • multiparous, but not virgin, females develop mammary gland carcinomas

neoplasm

increased mammary adenocarcinoma incidence ( J:149661 )

♀ • 13 of 21 multiparous females develop mammary carcinomas

♀ • females show varying frequencies of mammary gland hyperplasia, mammary intraepithelial neoplasia, invasive mammary carcinoma and metastasis to other organs

increased mammary gland tumor incidence in breeding females ( J:149661 )

♀ • multiparous, but not virgin, females develop mammary gland carcinomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:149661