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Phenotypes Associated with This Genotype
Genotype
MGI:5763087
Allelic
Composition
Tg(MMTV-LPAR1)27Gbm/Tg(MMTV-LPAR1)27Gbm
Genetic
Background
FVB/N-Tg(MMTV-LPAR1)27Gbm
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
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phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 9 of 21 multiparous females develop mammary carcinomas
• females show varying frequencies of mammary gland hyperplasia, mammary intraepithelial neoplasia, invasive mammary carcinoma and metastasis to other organs
• multiparous, but not virgin, females develop mammary gland carcinomas

integument
• 9 of 21 multiparous females develop mammary carcinomas
• females show varying frequencies of mammary gland hyperplasia, mammary intraepithelial neoplasia, invasive mammary carcinoma and metastasis to other organs
• multiparous, but not virgin, females develop mammary gland carcinomas

neoplasm
• 9 of 21 multiparous females develop mammary carcinomas
• females show varying frequencies of mammary gland hyperplasia, mammary intraepithelial neoplasia, invasive mammary carcinoma and metastasis to other organs
• multiparous, but not virgin, females develop mammary gland carcinomas

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
J:149661


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory