Phenotypes Associated with This Genotype

Genotype
MGI:5763104

• Allelic Composition: Tg(MMTV-LPAR2)6Gbm/Tg(MMTV-LPAR2)6Gbm
• Genetic Background: FVB/N-Tg(MMTV-LPAR2)6Gbm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal mammary gland morphology ( J:149661 )

♀ • mammary glands from virgin females show a slight increase in side branching

increased mammary adenocarcinoma incidence ( J:149661 )

♀ • 15 of 28 multiparous females develop mammary carcinomas

♀ • females show varying frequencies of mammary gland hyperplasia, mammary intraepithelial neoplasia, and invasive mammary carcinoma

increased mammary gland tumor incidence in breeding females ( J:149661 )

♀ • multiparous, but not virgin, females develop mammary gland carcinomas

mastitis ( J:149661 )

♀ • mammary glands show chronic mastitis indicative of chronic inflammation prior to development of tumors

immune system

mastitis ( J:149661 )

♀ • mammary glands show chronic mastitis indicative of chronic inflammation prior to development of tumors

integument

abnormal mammary gland morphology ( J:149661 )

♀ • mammary glands from virgin females show a slight increase in side branching

increased mammary adenocarcinoma incidence ( J:149661 )

♀ • 15 of 28 multiparous females develop mammary carcinomas

♀ • females show varying frequencies of mammary gland hyperplasia, mammary intraepithelial neoplasia, and invasive mammary carcinoma

increased mammary gland tumor incidence in breeding females ( J:149661 )

♀ • multiparous, but not virgin, females develop mammary gland carcinomas

mastitis ( J:149661 )

♀ • mammary glands show chronic mastitis indicative of chronic inflammation prior to development of tumors

neoplasm

increased mammary adenocarcinoma incidence ( J:149661 )

♀ • 15 of 28 multiparous females develop mammary carcinomas

♀ • females show varying frequencies of mammary gland hyperplasia, mammary intraepithelial neoplasia, and invasive mammary carcinoma

increased mammary gland tumor incidence in breeding females ( J:149661 )

♀ • multiparous, but not virgin, females develop mammary gland carcinomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:149661