Phenotypes Associated with This Genotype

Genotype
MGI:5763106

• Allelic Composition: Tg(MMTV-LPAR2)#Gbm/Tg(MMTV-LPAR2)#Gbm
• Genetic Background: FVB/N-Tg(MMTV-LPAR2)#Gbm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:149661 )

♀ • 52.8% incidence of mammary carcinoma with average onset of 16.5 months

♀ • 21.8% of mammary tumors are estrogen receptor alpha-positive

increased mammary gland tumor incidence in breeding females ( J:149661 )

♀ • multiparous, but not virgin, females develop mammary gland carcinomas

mastitis ( J:149661 )

♀ • mammary glands show chronic mastitis indicative of chronic inflammation prior to development of tumors

immune system

mastitis ( J:149661 )

♀ • mammary glands show chronic mastitis indicative of chronic inflammation prior to development of tumors

integument

increased mammary adenocarcinoma incidence ( J:149661 )

♀ • 52.8% incidence of mammary carcinoma with average onset of 16.5 months

♀ • 21.8% of mammary tumors are estrogen receptor alpha-positive

increased mammary gland tumor incidence in breeding females ( J:149661 )

♀ • multiparous, but not virgin, females develop mammary gland carcinomas

mastitis ( J:149661 )

♀ • mammary glands show chronic mastitis indicative of chronic inflammation prior to development of tumors

neoplasm

increased mammary adenocarcinoma incidence ( J:149661 )

♀ • 52.8% incidence of mammary carcinoma with average onset of 16.5 months

♀ • 21.8% of mammary tumors are estrogen receptor alpha-positive

increased mammary gland tumor incidence in breeding females ( J:149661 )

♀ • multiparous, but not virgin, females develop mammary gland carcinomas

increased metastatic potential ( J:149661 )

♀ • 7.1% of mice show metastasis to other organs

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:149661