Phenotypes Associated with This Genotype

Genotype
MGI:5763113

• Allelic Composition: Tg(MMTV-LPAR3)#Gbm/Tg(MMTV-LPAR3)#Gbm
• Genetic Background: FVB/N-Tg(MMTV-LPAR3)#Gbm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:149661 )

♀ • 42.3% incidence of mammary carcinoma with average onset of 19.5 months

♀ • 47.3% of mammary tumors are estrogen receptor alpha-positive

♀ • tumors include adenocarcinomas, adenosquamous carcinomas, or a combination of both

increased mammary gland tumor incidence in breeding females ( J:149661 )

♀ • multiparous, but not virgin, females develop mammary gland carcinomas

mastitis ( J:149661 )

♀ • mammary glands show chronic mastitis indicative of chronic inflammation prior to development of tumors

immune system

mastitis ( J:149661 )

♀ • mammary glands show chronic mastitis indicative of chronic inflammation prior to development of tumors

integument

increased mammary adenocarcinoma incidence ( J:149661 )

♀ • 42.3% incidence of mammary carcinoma with average onset of 19.5 months

♀ • 47.3% of mammary tumors are estrogen receptor alpha-positive

♀ • tumors include adenocarcinomas, adenosquamous carcinomas, or a combination of both

increased mammary gland tumor incidence in breeding females ( J:149661 )

♀ • multiparous, but not virgin, females develop mammary gland carcinomas

mastitis ( J:149661 )

♀ • mammary glands show chronic mastitis indicative of chronic inflammation prior to development of tumors

neoplasm

increased mammary adenocarcinoma incidence ( J:149661 )

♀ • 42.3% incidence of mammary carcinoma with average onset of 19.5 months

♀ • 47.3% of mammary tumors are estrogen receptor alpha-positive

♀ • tumors include adenocarcinomas, adenosquamous carcinomas, or a combination of both

increased mammary gland tumor incidence in breeding females ( J:149661 )

♀ • multiparous, but not virgin, females develop mammary gland carcinomas

increased metastatic potential ( J:149661 )

♀ • 45.5% metastatic rate, with sites of metastasis in regional lymphoma nodes and lung

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:149661