Phenotypes Associated with This Genotype

Genotype
MGI:5763241

• Allelic Composition: Tg(Fabp4-Phb)#Smis/0
• Genetic Background: involves: CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

decreased corpora lutea number ( J:242981 )

♀ • reduction in corpus luteum number or their absence

impaired ovarian folliculogenesis ( J:242981 )

♀ • arrest of follicular development

enlarged ovary ( J:242981 )

♀ • ovaries from about 25% of 9 month old mice are enlarged due to formation of ovarian cysts

ovary cyst ( J:242981 )

♀ • about 25% of females exhibit ovarian cysts filled with serous fluid at 9 months of age

♀ • ovarian cysts often develop bilaterally

adipose tissue

abnormal adipose tissue amount ( J:230172 , J:242981 )

• females accumulate more visceral fat, but less brown adipose tissue, than males, while subcutaneous fat mass increases similarly in females and males (J:230172)

• increase in adipose tissue mass (J:230172)

♀ • ovaries are surrounded by overgrowth of adipose tissue and periovarian adipose tissue closely associated with the ovarian epithelial surface (J:242981)

increased brown adipose tissue amount ( J:230172 )

♂ • males show increased fat accumulation in brown adipose tissue

abnormal brown fat cell morphology ( J:230172 )

• reduction in mitochondrial size, but not content, in brown adipose tissue

abnormal white adipose tissue morphology ( J:230172 )

♂ • white adipose tissue from males shows increased distribution of crown-like structures, indicating macrophage infiltration

increased subcutaneous adipose tissue amount ( J:230172 )

abnormal white fat cell morphology ( J:230172 )

• increase in mitochondrial number and distribution throughout the cytoplasmic rim of white adipocytes

• mitochondria in adipocytes is predominately elongated instead of round

increased white fat cell size ( J:230172 )

• adipocyte hypertrophy in white adipose tissue

abnormal white adipose tissue physiology ( J:230172 )

♂ • insulin-induced free fatty acid uptake by white adipose tissue is decreased in males

♂ • however, no change in fatty acid oxidation is seen

integument

increased subcutaneous adipose tissue amount ( J:230172 )

reproductive system

decreased corpora lutea number ( J:242981 )

♀ • reduction in corpus luteum number or their absence

impaired ovarian folliculogenesis ( J:242981 )

♀ • arrest of follicular development

enlarged ovary ( J:242981 )

♀ • ovaries from about 25% of 9 month old mice are enlarged due to formation of ovarian cysts

ovary cyst ( J:242981 )

♀ • about 25% of females exhibit ovarian cysts filled with serous fluid at 9 months of age

♀ • ovarian cysts often develop bilaterally

anovulation ( J:242981 )

♀

female infertility ( J:242981 )

♀ • 25% of females become infertile by 9 months of age

reduced female fertility ( J:242981 )

♀ • reduction in fecundity with aging

decreased litter size ( J:242981 )

• litter sizes at 9 months of age are greatly reduced

behavior/neurological

decreased locomotor activity ( J:230172 )

• reduction in horizontal activity

growth/size/body

enlarged ovary ( J:242981 )

♀ • ovaries from about 25% of 9 month old mice are enlarged due to formation of ovarian cysts

ovary cyst ( J:242981 )

♀ • about 25% of females exhibit ovarian cysts filled with serous fluid at 9 months of age

♀ • ovarian cysts often develop bilaterally

obese ( J:230172 , J:242981 )

• mice gain weight beginning at around 1 month of age and become obese by 2-3 months of age (J:230172)

• however, food intake is normal (J:230172)

♀ (J:242981)

homeostasis/metabolism

increased circulating estradiol level ( J:242981 )

♀ • serum estradiol levels are elevated

♀ • however, serum luteinizing hormone and testosterone levels are normal during ovarian cyst development

decreased circulating ghrelin level ( J:230172 )

♂ • in fasting and fed males

increased circulating insulin level ( J:230172 )

♂ • serum insulin levels are higher in fasted and fed males but not in females

increased circulating leptin level ( J:230172 )

♂ • increase in leptin levels in males

decreased circulating cholesterol level ( J:230172 )

♀ • decrease in serum cholesterol levels in females

increased circulating free fatty acids level ( J:230172 )

♂ • increase in free fatty acid levels in fed males

decreased circulating glycerol level ( J:230172 )

♀ • decrease in serum glycerol levels in fasted and fed females

decreased circulating triglyceride level ( J:230172 )

♀ • decrease in serum triglyceride levels in fasted and fed females

impaired glucose tolerance ( J:230172 )

♂ • males, but not females, have impaired glucose tolerance

insulin resistance ( J:230172 )

♂ • males, but not females, have impaired insulin tolerance

increased adiponectin level ( J:230172 , J:242981 )

♀ • increase in adiponectin levels in females but not males (J:230172)

♀ • 9 month old mice exhibit an increase in adiponectin levels (J:242981)

♀ • however, mice exhibit normal glucose homeostasis and insulin sensitivity and normal leptin and resistin levels at 9 months of age (J:242981)

liver/biliary system

hepatic steatosis ( J:230172 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:230172