Phenotypes Associated with This Genotype

Genotype
MGI:5763438

• Allelic Composition: Smarca4^tm1Mag/Smarca4⁺
• Genetic Background: involves: 129S/Sv * C57BL/6J * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:132091 )

• 12 of 130 mice develop tumors, with a latency period from 7 to 19 months and median of 14 months; most are females with one male developing a mammary gland tumor

• tumors are subcutaneous and located along the ventral or ventral-lateral surface from the neck to the inguinal region

• tumors are mammary adenocarcinoma or carcinoma, exhibiting trabecular/papillary or well-differentiated squamous cell morphology

• all tumors are malignant

• tumors do not undergo loss of heterozygosity and exhibit genomic instability

increased osteosarcoma incidence ( J:132091 )

♂

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:132091 )

• 12 of 130 mice develop tumors, with a latency period from 7 to 19 months and median of 14 months; most are females with one male developing a mammary gland tumor

• tumors are subcutaneous and located along the ventral or ventral-lateral surface from the neck to the inguinal region

• tumors are mammary adenocarcinoma or carcinoma, exhibiting trabecular/papillary or well-differentiated squamous cell morphology

• all tumors are malignant

• tumors do not undergo loss of heterozygosity and exhibit genomic instability

integument

increased mammary adenocarcinoma incidence ( J:132091 )

• 12 of 130 mice develop tumors, with a latency period from 7 to 19 months and median of 14 months; most are females with one male developing a mammary gland tumor

• tumors are subcutaneous and located along the ventral or ventral-lateral surface from the neck to the inguinal region

• tumors are mammary adenocarcinoma or carcinoma, exhibiting trabecular/papillary or well-differentiated squamous cell morphology

• all tumors are malignant

• tumors do not undergo loss of heterozygosity and exhibit genomic instability

skeleton

increased osteosarcoma incidence ( J:132091 )

♂

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:227323