Phenotypes Associated with This Genotype

Genotype
MGI:5766943

• Allelic Composition: Mex3b^tm1.1Mbld/Mex3b^tm1.1Mbld; Plekha5^{Tg(AMH-cre)1Flor}/Plekha5⁺
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:213588 )

N • mice exhibit no perinatal lethality, unlike Mex3b^tm1.2Mbld homozygotes

growth/size/body

growth/size/body region phenotype ( J:213588 )

N • mice exhibit no defect in postnatal growth, unlike Mex3b^tm1.2Mbld homozygotes

reproductive system

abnormal seminiferous tubule morphology ( J:213588 )

♂ • at 1 and 2 months of age, mice exhibit obstructed seminiferous tubules at a ratio that is very similar to that seen in male Mex3b^tm1.2Mbld homozygotes

♂ • tubule lumens are obstructed at stages V and VIII whereas those of control mice are empty (stages VIII and XI)

increased Sertoli cell number ( J:213588 )

♂ • at 1 and 2 months of age, mice exhibit a decreased ratio between germ and Sertoli cells, in the same order of magnitude as that seen in Mex3b^tm1.2Mbld homozygotes

abnormal Sertoli cell barrier function ( J:213588 )

♂ • mice exhibit altered permeability of the blood-testis barrier (BTB) leading to the production of anti-sperm antibodies

reduced male fertility ( J:213588 )

♂ • upon breeding with Mex3b^tm1.1Mbld female homozygotes, males exhibit a reduction in fertility similar to that observed upon breeding of Mex3b^tm1.2Mbld male homozygotes with wild-type females

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:213588 )

♂ • at 1 and 2 months of age, mice exhibit obstructed seminiferous tubules at a ratio that is very similar to that seen in male Mex3b^tm1.2Mbld homozygotes

♂ • tubule lumens are obstructed at stages V and VIII whereas those of control mice are empty (stages VIII and XI)

increased Sertoli cell number ( J:213588 )

♂ • at 1 and 2 months of age, mice exhibit a decreased ratio between germ and Sertoli cells, in the same order of magnitude as that seen in Mex3b^tm1.2Mbld homozygotes

abnormal Sertoli cell barrier function ( J:213588 )

♂ • mice exhibit altered permeability of the blood-testis barrier (BTB) leading to the production of anti-sperm antibodies

immune system

increased anti-sperm antibody level ( J:213588 )

♂ • mice exhibit increased levels of anti-sperm cell antibodies in the serum, indicating that BTB integrity is impaired