Phenotypes Associated with This Genotype

Genotype
MGI:5770790

• Allelic Composition: Tg(CAG-TRIM29)ADims/0
• Genetic Background: FVB/NJ-Tg(CAG-TRIM29)ADims

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased urinary bladder carcinoma incidence ( J:226764 )

• mice exhibit a spectrum of urothelial neoplasia ranging from dysplasia to muscle-invasive urothelial carcinoma that resembles human urothelial carcinomas

• 14% of mice develop only low-grade noninvasive tumors

• 29% of mice develop either invasive carcinoma or carcinoma-in-situ

• all invasive tumors show muscle invasion and muscle-invasive tumors consist of malignant cells infiltrating into the muscularis

• papillary carcinomas are multifocal with fibrovascular stalks projecting into the bladder lumen

• PTEN protein expression is lost in both noninvasive and muscle-invasive bladder cancers

renal/urinary system

increased urinary bladder carcinoma incidence ( J:226764 )

• mice exhibit a spectrum of urothelial neoplasia ranging from dysplasia to muscle-invasive urothelial carcinoma that resembles human urothelial carcinomas

• 14% of mice develop only low-grade noninvasive tumors

• 29% of mice develop either invasive carcinoma or carcinoma-in-situ

• all invasive tumors show muscle invasion and muscle-invasive tumors consist of malignant cells infiltrating into the muscularis

• papillary carcinomas are multifocal with fibrovascular stalks projecting into the bladder lumen

• PTEN protein expression is lost in both noninvasive and muscle-invasive bladder cancers

urinary bladder obstruction ( J:226764 )

• mice develop bladder outlet obstruction secondary to tumor formation starting at 8 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
urinary bladder cancer		DOID:11054	OMIM:109800	J:226764