Phenotypes Associated with This Genotype

Genotype
MGI:5774862

• Allelic Composition: Tg(Thy1-MAPT*L266V*G272V)13Ema/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal habituation to a new environment ( J:229181 )

• mice display a continued high activity and failure to habituate to a novel environment

impaired spatial learning ( J:229181 )

• during the hidden portion of the water maze, mutants require a longer distance and time to find the platform compared to controls

• however, during the cued portion of the water maze, mutants perform similarly to controls

abnormal spatial reference memory ( J:229181 )

• on day 7, during the probe portion of the water maze, mice show impairments in memory retention

increased thigmotaxis ( J:229181 )

impaired coordination ( J:229181 )

• 6-8 and 12-14 month old mice, but not 3-4 month old mice, show impairments when crossing a round beam, with a higher rate of errors

hyperactivity ( J:229181 )

• increase in total activity beginning at 3-4 months of age with a time dependent increase 6-8 and 12-14 months of age

increased vertical activity ( J:229181 )

nervous system

abnormal dentate gyrus morphology ( J:229181 )

• 8-10 month old mice show alterations in the mitochondria of the hippocampus dentate gyrus, with some enlarged and elongated mitochondria that display disorganized cresta

decreased neocortex volume ( J:229181 )

• decrease in the neocortical volume

tau protein deposits ( J:229181 )

• age dependent increase in tau protein aggregation in layer II-III and V pyramidal neurons in the neocortex and pyramidal and granular cells in the hippocampus

• tau accumulates in synaptohysin positive presynaptic terminals and in MAP2 immunoreactive dendrites

abnormal dendrite morphology ( J:229181 )

• dendrites show accumulation of lamellar bodies and straight filamentous structures

decreased neuron number ( J:229181 )

• reduction in the number of neurons in the CA1 and dentate gyrus of the hippocampus

neuronal intranuclear inclusions ( J:229181 )

• intra-neuronal inclusions in the frontal cortex

neurodegeneration ( J:229181 )

• increase in GFAP immunoreactivity in the neocortex and hippocampus and glial cells are detected in the hippocampus indicating neurodegeneration

axonal dystrophy ( J:229181 )

• axonal dystrophy in 8-10 month old mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Pick's disease		DOID:11870	OMIM:172700	J:229181