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Phenotypes Associated with This Genotype
Genotype
MGI:5775190
cn3
Allelic
Composition		 Engtm2.1Hma/Engtm2.1Hma
Tg(Tal1-cre/ERT)1Jrg/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Engtm2.1Hma mutation (1 available); any Eng mutation (43 available)
Tg(Tal1-cre/ERT)1Jrg mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
arteriovenous malformation ( J:227170 )
• tamoxifen-injected adults subjected to wounding exhibit multiple arteriovenous (AV) shunts in the punched area of both the ear and the back skin
abnormal vascular wound healing ( J:227170 )
• tamoxifen-injected adults subjected to wounding exhibit tortuous and enlarged blood vessels and present multiple arteriovenous (AV) shunts in the punched area of both the ear and the back skin
• however, tamoxifen-treated mice do not exhibit signs of hemorrhages or arteriovenous malformations in internal organs and survive longer than a month

homeostasis/metabolism
abnormal vascular wound healing ( J:227170 )
• tamoxifen-injected adults subjected to wounding exhibit tortuous and enlarged blood vessels and present multiple arteriovenous (AV) shunts in the punched area of both the ear and the back skin
• however, tamoxifen-treated mice do not exhibit signs of hemorrhages or arteriovenous malformations in internal organs and survive longer than a month

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory