cardiovascular system
• tamoxifen-treated mice show multiple arteriovenous (AV) shunts in the ear and skin wound areas
|
• tamoxifen-treated mice exhibit arteriovenous malformations in gastrointestinal tract
|
• tamoxifen-treated mice exhibit severe hemorrhages in the cecum
|
• tamoxifen-treated mice show multiple arteriovenous (AV) shunts in the ear and skin wound areas
• vessels associated with AV shunts are tortuous, enlarged, and present characteristic loops
|
digestive/alimentary system
• tamoxifen-treated mice exhibit arteriovenous malformations in gastrointestinal tract
|
• tamoxifen-treated mice exhibit severe hemorrhages in the cecum
|
homeostasis/metabolism
• tamoxifen-treated mice show multiple arteriovenous (AV) shunts in the ear and skin wound areas
• vessels associated with AV shunts are tortuous, enlarged, and present characteristic loops
|
mortality/aging
• survival rate is about 2 weeks on average after first tamoxifen injection
• lethality is most likely associated with gastrointestinal hemorrhages
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
hereditary hemorrhagic telangiectasia | DOID:1270 |
OMIM:187300 OMIM:600376 OMIM:615506 |
J:227170 |