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Phenotypes Associated with This Genotype
Genotype
MGI:5775199
Allelic
Composition
Acvrl1tm2.1Spo/Acvrl1tm2.1Spo
Tg(Tal1-cre/ERT)1Jrg/0
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvrl1tm2.1Spo mutation (0 available); any Acvrl1 mutation (27 available)
Tg(Tal1-cre/ERT)1Jrg mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• tamoxifen-treated mice show multiple arteriovenous (AV) shunts in the ear and skin wound areas
• tamoxifen-treated mice exhibit arteriovenous malformations in gastrointestinal tract
• tamoxifen-treated mice exhibit severe hemorrhages in the cecum
• tamoxifen-treated mice show multiple arteriovenous (AV) shunts in the ear and skin wound areas
• vessels associated with AV shunts are tortuous, enlarged, and present characteristic loops

digestive/alimentary system
• tamoxifen-treated mice exhibit arteriovenous malformations in gastrointestinal tract
• tamoxifen-treated mice exhibit severe hemorrhages in the cecum

homeostasis/metabolism
• tamoxifen-treated mice show multiple arteriovenous (AV) shunts in the ear and skin wound areas
• vessels associated with AV shunts are tortuous, enlarged, and present characteristic loops

mortality/aging
• survival rate is about 2 weeks on average after first tamoxifen injection
• lethality is most likely associated with gastrointestinal hemorrhages

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hereditary hemorrhagic telangiectasia DOID:1270 OMIM:187300
OMIM:600376
OMIM:615506
J:227170


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory