Phenotypes Associated with This Genotype

Genotype
MGI:5776354

• Allelic Composition: Shank3^tm5.1Gfng/Shank3^tm5.1Gfng
• Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased exploration in new environment ( J:229668 )

• decreased total distance travelled in open field test as compared to controls

increased anxiety-related response ( J:229668 )

• mice spend less time in open arm during elevated zero maze test as compared to controls

increased grooming behavior ( J:229668 )

• repetitive grooming

impaired coordination ( J:229668 )

• impaired motor coordination in rotarod test

nervous system

decreased excitatory postsynaptic current amplitude ( J:229668 )

• decreased pop spike amplitude in the dorsal striatum as compared to controls

• presynaptic function, as determined by relationship of stimulation intensity to negative peak amplitude, is similar to control

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:229668