Phenotypes Associated with This Genotype

Genotype
MGI:5779426

• Allelic Composition: Ncstn^tm1.1Akli/Ncstn^tm1.1Akli; Tg(Upk2-cre,-EGFP)#Akli/0
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased urinary bladder carcinoma incidence ( J:227748 )

• within 2-6 months of age, mice develop bladder tumors that consist of simple and nodular hyperplasia, as well as high-grade dysplasia and carcinoma in situ showing basal characteristics

renal/urinary system

increased urinary bladder carcinoma incidence ( J:227748 )

• within 2-6 months of age, mice develop bladder tumors that consist of simple and nodular hyperplasia, as well as high-grade dysplasia and carcinoma in situ showing basal characteristics

hydronephrosis ( J:227748 )

• mice develop occasional unilateral hydronephrosis within 2-6 months due to ureter obstruction

ureter obstruction ( J:227748 )

• due to bladder tumors

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
urinary bladder cancer		DOID:11054	OMIM:109800	J:227748