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Phenotypes Associated with This Genotype
Genotype
MGI:5779541
Allelic
Composition		 Apctm1Tno/Apctm1Tno
Ptentm2Mak/Ptentm2Mak
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1Tno mutation (6 available); any Apc mutation (154 available)
Ptentm2Mak mutation (4 available); any Pten mutation (82 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased tumor-free survival time ( J:120955 )
• mice die within 19 weeks (range 7-19 weeks, average 11.5 weeks) after AdCre injection into the ovarian bursa and development of ovarian tumors

neoplasm
increased ovarian carcinoma incidence ( J:120955 )
• 8-10 week old mice injected with an adenovirus expressing cre recombinase (AdCre) into the right ovarian bursa develop ovarian carcinoma with 100% penetrance within 6 weeks of AdCre injection
• tumors show similarity to human ovarian endometrioid adenocarcinoma, with formation of distinct glands and occasional foci of squamous differentiation

endocrine/exocrine glands
increased ovarian carcinoma incidence ( J:120955 )
• 8-10 week old mice injected with an adenovirus expressing cre recombinase (AdCre) into the right ovarian bursa develop ovarian carcinoma with 100% penetrance within 6 weeks of AdCre injection
• tumors show similarity to human ovarian endometrioid adenocarcinoma, with formation of distinct glands and occasional foci of squamous differentiation

homeostasis/metabolism
hemorrhagic ascites ( J:120955 )
• 76% of ovarian bursa AdCre injected mice develop hemorrhagic ascites and 21% develop overt peritoneal dissemination of tumors

reproductive system
increased ovarian carcinoma incidence ( J:120955 )
• 8-10 week old mice injected with an adenovirus expressing cre recombinase (AdCre) into the right ovarian bursa develop ovarian carcinoma with 100% penetrance within 6 weeks of AdCre injection
• tumors show similarity to human ovarian endometrioid adenocarcinoma, with formation of distinct glands and occasional foci of squamous differentiation

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
ovarian cancer DOID:2394 OMIM:167000
OMIM:607893
 J:120955

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory