Phenotypes Associated with This Genotype

Genotype
MGI:5779560

cx22

• Allelic Composition: Ctss^tm1Hap/Ctss^tm1Hap; Dmd^mdx/Dmd^mdx
• Genetic Background: involves: 129S2/SvPas * C57BL/10ScSn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired exercise endurance ( J:230788 )

• treadmill running time is decreased as compared to wild-type, but increased as compared to homozygous Dmd^mdx mice

homeostasis/metabolism

impaired exercise endurance ( J:230788 )

• treadmill running time is decreased as compared to wild-type, but increased as compared to homozygous Dmd^mdx mice

increased circulating creatine kinase level ( J:230788 )

• increase in serum creatine kinase levels as compared to wild-type, but decreased as compared to homozygous Dmd^mdx mic

muscle

abnormal skeletal muscle fiber morphology ( J:230788 )

• decreased membrane stability as compared to wild-type, but increased as compared to homozygous Dmd^mdx mice

centrally nucleated skeletal muscle fibers ( J:230788 )

• increase in central nucleation at 2 and 10 months of age as compared to wild-type, but decreased as compared to homozygous Dmd^mdx mice

skeletal muscle fiber necrosis ( J:230788 )

• myofiber necrosis is increased as compared to wild-type, but decreased as compared to homozygous Dmd^mdx mic

skeletal muscle fibrosis ( J:230788 )

• fibrosis at 2 months and 10 months is increased as compared to wild-type, but decreased as compared to homozygous Dmd^mdx mice

dystrophic muscle ( J:230788 )

• increased as compared to wild-type, but decreased as compared to homozygous Dmd^mdx mice