Analysis Tools
cardiovascular system
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• hearts of tamoxifen-treated mice exhibit normal cardiac adaptation to long-term stress induced by transverse aortic constriction
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• tamoxifen-treated mice exhibit inhibited acute cardiac mitochondrial calcium uptake compared with control cells
• at 18 weeks, cardiac myocytes from tamoxifen-treated mice challenged with calcium exhibit a severely blunted compared with control cells
• cardiac myocytes from tamoxifen-treated mice exhibit lower sodium-induced calcium efflux rates compared with control cells
• cardiac mitochondria from mice treated with tamoxifen and dobutamine fail to exhibit an increase in calcium unlike control mitochondria
• however, mice exhibit normal baseline mitochondrial calcium levels, response to Ru360, and elevated calcium levels in the mitochondrial following sustained dobutamine treatment
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• tamoxifen-treated mice subjected to dobutamine (the beta-adrenergic receptor agonist) exhibit lesser short-term increase in the maximal rate of cardiac pressure compared with control mice
• however, sustained administration of dobutamine at 32 ng/g/min induced similar ventricular pressure
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• cardiomyocytes from tamoxifen treated mice fail to exhibit an increase in mitochondrial oxygen consumption and ATP utilization compared with control mice
• however, baseline mitochondrial oxygen consumption and ATP utilization are normal
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• in tamoxifen treated mice
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homeostasis/metabolism
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• under the short warm-up/high-intensity sprinting regimen, tamoxifen-treated mice exhibit reduced running capacity compared with control mice
• however, the difference is lost with a longer warm-up period
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• in tamoxifen treated mice
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behavior/neurological
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• under the short warm-up/high-intensity sprinting regimen, tamoxifen-treated mice exhibit reduced running capacity compared with control mice
• however, the difference is lost with a longer warm-up period
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cellular
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• in cardiomyocytes from tamoxifen treated mice in response to ionomycin
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muscle
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• tamoxifen-treated mice exhibit inhibited acute cardiac mitochondrial calcium uptake compared with control cells
• at 18 weeks, cardiac myocytes from tamoxifen-treated mice challenged with calcium exhibit a severely blunted compared with control cells
• cardiac myocytes from tamoxifen-treated mice exhibit lower sodium-induced calcium efflux rates compared with control cells
• cardiac mitochondria from mice treated with tamoxifen and dobutamine fail to exhibit an increase in calcium unlike control mitochondria
• however, mice exhibit normal baseline mitochondrial calcium levels, response to Ru360, and elevated calcium levels in the mitochondrial following sustained dobutamine treatment
|
|
• tamoxifen-treated mice subjected to dobutamine (the beta-adrenergic receptor agonist) exhibit lesser short-term increase in the maximal rate of cardiac pressure compared with control mice
• however, sustained administration of dobutamine at 32 ng/g/min induced similar ventricular pressure
|
|
• in cardiomyocytes from tamoxifen treated mice in response to ionomycin
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