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Phenotypes Associated with This Genotype
Genotype
MGI:5780987
Allelic
Composition
Nexntm1.1Zhh/Nexntm1.1Zhh
Genetic
Background
involves: C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nexntm1.1Zhh mutation (0 available); any Nexn mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• many mice die in the first two days after birth
• nearly all mice die within 8 days after birth
• however, one mouse survived

cardiovascular system
• wall thinning at P6
• lower anterior and posterior wall thickness in diastole are lower than in wild-type mice
• however, sarcomeres are normal
• 2.3-fold at P4
• internal diameter in diastole and systole
• rapidly progressive
• endomyocardial fibroelastosis

muscle

growth/size/body
• 2.3-fold at P4

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hypertrophic cardiomyopathy 20 DOID:0110326 OMIM:613876
J:228046


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory