mortality/aging
• many mice die in the first two days after birth
• nearly all mice die within 8 days after birth
• however, one mouse survived
|
cardiovascular system
• wall thinning at P6
• lower anterior and posterior wall thickness in diastole are lower than in wild-type mice
• however, sarcomeres are normal
|
• 2.3-fold at P4
|
• internal diameter in diastole and systole
|
• rapidly progressive
|
• endomyocardial fibroelastosis
|
muscle
growth/size/body
• 2.3-fold at P4
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
hypertrophic cardiomyopathy 20 | DOID:0110326 |
OMIM:613876 |
J:228046 |