Phenotypes Associated with This Genotype

Genotype
MGI:5784489

• Allelic Composition: Foxo1^tm1Rdp/Foxo1^tm1.1Rdp; Foxo3^tm1Rdp/Foxo3^tm1.1Rdp; Amhr2^tm3(cre)Bhr/Amhr2⁺
• Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal ovarian follicle morphology ( J:232961 )

♀ • ovaries of 3-4 month old mice contain many small abnormal follicles in which fragmented oocytes or only remnants of the zona pellucida are evident

♀ • some follicles in 3-4 month old mice assume the appearance of testicular-like structures

increased granulosa cell tumor incidence ( J:232961 )

♀ • about 20% of mice develop granulosa cell tumors by 6-8 months of age

♀ • most tumors from 6-11 months of age are unilateral and solid with regions of trabecular- and gyriform-like structures

♀ • some tumors contain cystic or hemorrhagic follicle-like structures devoid of oocytes and/or regions of necrosis

ovary cyst ( J:232961 )

♀ • ovaries of 3-4 month old mice typically contain large cyst-like structures, some of which are hemorrhagic

homeostasis/metabolism

abnormal circulating hormone level ( J:232961 )

♀ • tumor bearing mice exhibit increased levels of serum inhibin A and inhibin B

increased circulating estradiol level ( J:232961 )

♀ • serum levels of estradiol are elevated in tumor bearing mice

suppressed circulating follicle stimulating hormone level ( J:232961 )

♀ • serum follicle stimulating hormone levels are below the level of detection in tumor bearing mice

decreased circulating luteinizing hormone level ( J:232961 )

♀ • serum luteinizing hormone levels are below the level of detection in tumor bearing mice

neoplasm

increased granulosa cell tumor incidence ( J:232961 )

♀ • about 20% of mice develop granulosa cell tumors by 6-8 months of age

♀ • most tumors from 6-11 months of age are unilateral and solid with regions of trabecular- and gyriform-like structures

♀ • some tumors contain cystic or hemorrhagic follicle-like structures devoid of oocytes and/or regions of necrosis

reproductive system

abnormal ovarian follicle morphology ( J:232961 )

♀ • ovaries of 3-4 month old mice contain many small abnormal follicles in which fragmented oocytes or only remnants of the zona pellucida are evident

♀ • some follicles in 3-4 month old mice assume the appearance of testicular-like structures

increased granulosa cell tumor incidence ( J:232961 )

♀ • about 20% of mice develop granulosa cell tumors by 6-8 months of age

♀ • most tumors from 6-11 months of age are unilateral and solid with regions of trabecular- and gyriform-like structures

♀ • some tumors contain cystic or hemorrhagic follicle-like structures devoid of oocytes and/or regions of necrosis

ovary cyst ( J:232961 )

♀ • ovaries of 3-4 month old mice typically contain large cyst-like structures, some of which are hemorrhagic

growth/size/body

ovary cyst ( J:232961 )

♀ • ovaries of 3-4 month old mice typically contain large cyst-like structures, some of which are hemorrhagic

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
ovarian cancer		DOID:2394	OMIM:167000 OMIM:607893	J:232961