Phenotypes Associated with This Genotype

Genotype
MGI:5784494

• Allelic Composition: Foxo1^tm1Rdp/Foxo1^tm1.1Rdp; Foxo3^tm1Rdp/Foxo3^tm1.1Rdp; Tg(CYP19A1-cre)1Jri/0
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal ovarian follicle morphology ( J:232961 )

♀ • 1.5 month old mice injected with superovulatory levels of equine gonadotropin and human gonadotropin exhibit ovaries with many abnormal, degenerating follicles in which oocytes are shrunken or absent

abnormal granulosa cell morphology ( J:232961 )

♀ • in some ovarian follicles of mice injected with superovulatory levels of equine gonadotropin and human gonadotropin, granulosa cells are abnormally displaced and growing on one side

increased granulosa cell tumor incidence ( J:232961 )

♀ • about 20% of mice develop granulosa cell tumors by 6-8 months of age

♀ • most tumors from 6-11 months of age are unilateral and solid with regions of trabecular- and gyriform-like structures

♀ • some tumors contain cystic or hemorrhagic follicle-like structures devoid of oocytes and/or regions of necrosis

♀ • 65% of 1.5 month old mice injected with superovulatory levels of equine gonadotropin and human gonadotropin develop granulosa cell tumors or cysts

homeostasis/metabolism

abnormal circulating hormone level ( J:232961 )

♀ • tumor bearing mice exhibit increased levels of serum inhibin A and inhibin B

increased circulating estradiol level ( J:232961 )

♀ • serum levels of estradiol are elevated in tumor bearing mice

suppressed circulating follicle stimulating hormone level ( J:232961 )

♀ • serum follicle stimulating hormone levels are below the level of detection in tumor bearing mice

decreased circulating luteinizing hormone level ( J:232961 )

♀ • serum luteinizing hormone levels are below the level of detection in tumor bearing mice

neoplasm

increased granulosa cell tumor incidence ( J:232961 )

♀ • about 20% of mice develop granulosa cell tumors by 6-8 months of age

♀ • most tumors from 6-11 months of age are unilateral and solid with regions of trabecular- and gyriform-like structures

♀ • some tumors contain cystic or hemorrhagic follicle-like structures devoid of oocytes and/or regions of necrosis

♀ • 65% of 1.5 month old mice injected with superovulatory levels of equine gonadotropin and human gonadotropin develop granulosa cell tumors or cysts

reproductive system

abnormal ovarian follicle morphology ( J:232961 )

♀ • 1.5 month old mice injected with superovulatory levels of equine gonadotropin and human gonadotropin exhibit ovaries with many abnormal, degenerating follicles in which oocytes are shrunken or absent

abnormal granulosa cell morphology ( J:232961 )

♀ • in some ovarian follicles of mice injected with superovulatory levels of equine gonadotropin and human gonadotropin, granulosa cells are abnormally displaced and growing on one side

increased granulosa cell tumor incidence ( J:232961 )

♀ • about 20% of mice develop granulosa cell tumors by 6-8 months of age

♀ • most tumors from 6-11 months of age are unilateral and solid with regions of trabecular- and gyriform-like structures

♀ • some tumors contain cystic or hemorrhagic follicle-like structures devoid of oocytes and/or regions of necrosis

♀ • 65% of 1.5 month old mice injected with superovulatory levels of equine gonadotropin and human gonadotropin develop granulosa cell tumors or cysts

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
ovarian cancer		DOID:2394	OMIM:167000 OMIM:607893	J:232961