Phenotypes Associated with This Genotype

Genotype
MGI:5784729

• Allelic Composition: Arid1a^tm1.1Mag/Arid1a⁺; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

small temporal bone squamous part ( J:231470 )

• smaller squamosal bones

short premaxilla ( J:231470 )

abnormal palatine bone morphology ( J:231470 )

• the anterior palatine length is reduced

short snout ( J:231470 )

lowered ear position ( J:231470 )

growth/size/body

short snout ( J:231470 )

lowered ear position ( J:231470 )

abnormal body composition ( J:231470 )

• body mass is lower

• however, mice show similar intercanthal distance and molar width as wild-type mice, suggesting that craniofacial defects are not due to proportional body size differences

hearing/vestibular/ear

lowered ear position ( J:231470 )

skeleton

small temporal bone squamous part ( J:231470 )

• smaller squamosal bones

short premaxilla ( J:231470 )

abnormal palatine bone morphology ( J:231470 )

• the anterior palatine length is reduced

vision/eye

enophthalmos ( J:231470 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Coffin-Siris syndrome		DOID:1925	OMIM:PS135900	J:231470