Phenotypes Associated with This Genotype

Genotype
MGI:5789334

• Allelic Composition: Tg(SFTPC-EGFR*L858R)4-3Kkiu/0
• Genetic Background: involves: C57BL/6Cr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:152157 )

• mice die at about 30 weeks of age

neoplasm

increased lung tumor incidence ( J:152157 )

• mice develop lung tumors after 7 weeks of age

• treatment of 3 week old mice with gefitinib prevents lung tumorigenesis completely

• one week after stopping gefitinib treatment of mice that had been treated with it for 15 weeks, reexpansion of tumors cells is seen

increased lung carcinoma incidence ( J:152157 )

• bronchioloalveolar carcinoma at 4-5 weeks of age

increased lung adenocarcinoma incidence ( J:152157 )

• at 7 weeks of age, adenocarcinoma with solid features is seen similar to human adenocarcinoma

• however, metastatic lesions are not seen in any other organ

respiratory system

increased lung tumor incidence ( J:152157 )

• mice develop lung tumors after 7 weeks of age

• treatment of 3 week old mice with gefitinib prevents lung tumorigenesis completely

• one week after stopping gefitinib treatment of mice that had been treated with it for 15 weeks, reexpansion of tumors cells is seen

increased lung carcinoma incidence ( J:152157 )

• bronchioloalveolar carcinoma at 4-5 weeks of age

increased lung adenocarcinoma incidence ( J:152157 )

• at 7 weeks of age, adenocarcinoma with solid features is seen similar to human adenocarcinoma

• however, metastatic lesions are not seen in any other organ

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung cancer		DOID:1324	OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210	J:152157