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Phenotypes Associated with This Genotype
Genotype
MGI:5789375
Allelic
Composition
Alktm1.1Ics/?
Tg(Th-MYCN)41Waw/0
Genetic
Background
involves: 129S2/SvPas * 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alktm1.1Ics mutation (0 available); any Alk mutation (64 available)
Tg(Th-MYCN)41Waw mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• tumors are classified as neuroblastoma, stroma-poor, poorly differentiated or differentiating (J:228124)
• tumor onset occurs later than in mice carrying the Alktm2.1Ics allele (J:228124)
• abdominal tumors are median, perivascular and locally invasive without evidence of macroscopic tumor spread to other organs (J:228124)
• tumors at 2 or 3 locations (abdominal/thoracic/cervical) are seen in 70% of mice (J:228124)
• mice treated with vandetanib, a kinase inhibitor, or crizotinib, show a reduction in abdominal tumor weight (J:228124)

mortality/aging
• mice begin to die around 100 days of age, with 70% survival at 200-300 days of age

nervous system
• tumors are classified as neuroblastoma, stroma-poor, poorly differentiated or differentiating (J:228124)
• tumor onset occurs later than in mice carrying the Alktm2.1Ics allele (J:228124)
• abdominal tumors are median, perivascular and locally invasive without evidence of macroscopic tumor spread to other organs (J:228124)
• tumors at 2 or 3 locations (abdominal/thoracic/cervical) are seen in 70% of mice (J:228124)
• mice treated with vandetanib, a kinase inhibitor, or crizotinib, show a reduction in abdominal tumor weight (J:228124)

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
neuroblastoma DOID:769 J:228124 , J:261033


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory