Phenotypes Associated with This Genotype

Genotype
MGI:5789554

• Allelic Composition: Tg(KRT19-TAg)7Eps/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased adrenal gland tumor incidence ( J:64395 )

• 7 of 28 mice develop adrenal neoplasia

increased prostate gland tumor incidence ( J:64395 )

• 4 of 17 males develop prostate/coagulation gland neoplasia

increased metastatic potential ( J:64395 )

• 5 of 20 mice show lung metastasis

increased urinary bladder transitional cell carcinoma incidence ( J:64395 )

• all mice develop invasive transitional cell carcinoma, a neoplasm of urinary bladder urothelial cells, by 12 weeks of age, resembling the nonpapillary form

• disease progresses from development of carcinoma insitu, stromal invasion, muscle invasion, rapid growth, and lung metastasis (in 20% of mice)

increased mesothelioma incidence ( J:64395 )

• 6 of 28 mice develop mesothelial neoplasia

mortality/aging

premature death ( J:64395 )

• all mice are sacrificed by 3 months of age due to the presence of high-grade disease

growth/size/body

slow postnatal weight gain ( J:64395 )

• reduction in weight gain, with mice weighing about 70% of controls at 9 weeks of age

enlarged kidney ( J:64395 )

• mice show 2-fold kidney enlargement

behavior/neurological

lethargy ( J:64395 )

• mice begin to develop lethargy at 10 weeks of age

endocrine/exocrine glands

enlarged adrenal glands ( J:64395 )

• mice show 2-fold adrenal enlargement

increased adrenal gland tumor incidence ( J:64395 )

• 7 of 28 mice develop adrenal neoplasia

prostate gland hyperplasia ( J:64395 )

• most males exhibit focal dysplasia and hyperplasia in prostatic/coagulation gland and seminal vesicle epithelium

increased prostate gland tumor incidence ( J:64395 )

• 4 of 17 males develop prostate/coagulation gland neoplasia

abnormal seminal vesicle epithelium morphology ( J:64395 )

• most males exhibit focal dysplasia and hyperplasia in the seminal vesicle epithelium

homeostasis/metabolism

increased blood urea nitrogen level ( J:64395 )

• blood urea nitrogen (BUN) is elevated 2.2-fold in mice with large neoplasms

• however, creatinine levels are unchanged

integument

ruffled hair ( J:64395 )

• mice begin to develop ruffled coats at 10 weeks of age

renal/urinary system

enlarged kidney ( J:64395 )

• mice show 2-fold kidney enlargement

increased urinary bladder transitional cell carcinoma incidence ( J:64395 )

• all mice develop invasive transitional cell carcinoma, a neoplasm of urinary bladder urothelial cells, by 12 weeks of age, resembling the nonpapillary form

• disease progresses from development of carcinoma insitu, stromal invasion, muscle invasion, rapid growth, and lung metastasis (in 20% of mice)

hydronephrosis ( J:64395 )

• seen occasionally

abnormal distal convoluted tubule morphology ( J:64395 )

• all mice exhibit hyperplasia and dysplasia of distal convoluted renal tubules

reproductive system

prostate gland hyperplasia ( J:64395 )

• most males exhibit focal dysplasia and hyperplasia in prostatic/coagulation gland and seminal vesicle epithelium

increased prostate gland tumor incidence ( J:64395 )

• 4 of 17 males develop prostate/coagulation gland neoplasia

abnormal seminal vesicle epithelium morphology ( J:64395 )

• most males exhibit focal dysplasia and hyperplasia in the seminal vesicle epithelium

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
urinary bladder cancer		DOID:11054	OMIM:109800	J:64395