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Phenotypes Associated with This Genotype
Genotype
MGI:5789748
Allelic
Composition		 Rb1tm2Brn/Rb1tm2Brn
Rbl1tm1Tyj/Rbl1tm1Tyj
Rbl2tm2Tyj/Rbl2tm2Tyj
Genetic
Background		 involves: 129 * 129S2/SvPas * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm2Brn mutation (3 available); any Rb1 mutation (111 available)
Rbl1tm1Tyj mutation (1 available); any Rbl1 mutation (60 available)
Rbl2tm2Tyj mutation (2 available); any Rbl2 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased urinary bladder carcinoma incidence ( J:217195 )
• mice injected with an adenovirus expressing cre-recombinase (AdCre) into the bladder lumen all develop bladder lesions that resemble high-grade non-muscle-invasive carcinoma
• bladder tumors display high proliferation and invade the basal lamina
• metastases are not seen for up to 1 year after AdCre infection

renal/urinary system
hematuria ( J:217195 )
• hematuria is sometimes seen in mice injected with AdCre into the bladder lumen with bladder lesions
increased urinary bladder carcinoma incidence ( J:217195 )
• mice injected with an adenovirus expressing cre-recombinase (AdCre) into the bladder lumen all develop bladder lesions that resemble high-grade non-muscle-invasive carcinoma
• bladder tumors display high proliferation and invade the basal lamina
• metastases are not seen for up to 1 year after AdCre infection

homeostasis/metabolism
hematuria ( J:217195 )
• hematuria is sometimes seen in mice injected with AdCre into the bladder lumen with bladder lesions

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
urinary bladder cancer DOID:11054 OMIM:109800
 J:217195

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory