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Phenotypes Associated with This Genotype
Genotype
MGI:5790500
Allelic
Composition		 Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
Krastm4Tyj/Kras+
Tg(Upk2-cre)6Xrw/0
Genetic
Background		 involves: 129S4/SvJae * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (49 available)
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Tg(Upk2-cre)6Xrw mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:234236 )
• mean survival of 185 days and median survival of 200 days

neoplasm
increased urinary bladder carcinoma incidence ( J:234236 )
• mice rapidly develop bladder tumors resembling urothelial cell carcinoma

renal/urinary system
increased urinary bladder carcinoma incidence ( J:234236 )
• mice rapidly develop bladder tumors resembling urothelial cell carcinoma

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
urinary bladder cancer DOID:11054 OMIM:109800
 J:234236

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory