Phenotypes Associated with This Genotype

Genotype
MGI:5790964

• Allelic Composition: Myo5b^tm1.1Cle/Myo5b^tm1.1Cle; Tg(Vil1-cre/ERT2)23Syr/0
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Microvillus inclusion disease phenotype in Myo5b^tm1.1Cle/Myo5b^tm1.1Cle Tg(Vil1-cre/ERT2)23Syr/0 mice

digestive/alimentary system

diarrhea ( J:227079 )

• tamoxifen induced mice exhibit watery diarrhea

abnormal intestinal epithelium morphology ( J:227079 )

• tamoxifen induced mice show intestinal crypt hyperplasia

• intercellular spaces between enterocytes are enlarged in tamoxifen induced mice

abnormal enterocyte morphology ( J:227079 )

• PAS-positive vesicles (secretory granules) are seen in crypt enterocytes and at the crypt-villus transition of tamoxifen treated mice

abnormal small intestinal villus morphology ( J:227079 )

• mature villus enterocytes show clusters of subapical vesicles, autolysosomes, and microvillus inclusions on day 4 after tamoxifen induction

• marker analysis indicates disturbed basolateral polarity of villus enterocytes in tamoxifen treated mice

• subapical accumulation of secretory granules precedes occurrence of microvillus inclusions

abnormal small intestinal microvillus morphology ( J:227079 )

• intestines show a severe reduction to almost complete absence of apical microvilli on day 4 after tamoxifen induction

fused small intestinal villi ( J:227079 )

• tamoxifen treated mice exhibit fusion of intestinal villi

small intestinal villus atrophy ( J:227079 )

• mice show intestinal villus atrophy on day 4 after tamoxifen induction

growth/size/body

weight loss ( J:227079 )

• mice exhibit severe weight loss starting from day 3 after tamoxifen induction

homeostasis/metabolism

dehydration ( J:227079 )

• tamoxifen induced mice exhibit dehydration

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
microvillus inclusion disease		DOID:0060775	OMIM:251850	J:227079