Phenotypes Associated with This Genotype

Genotype
MGI:5790977

• Allelic Composition: Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor^tm1Sor; Pten^tm1Mro/Pten^tm1Mro; Trp53^tm1Brn/Trp53^tm1Brn
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased glioma incidence ( J:229481 )

• mice injected with an adenovirus expressing cre recombinase (Ad-Cre) into the left ventricle exhibit a 33.3% incidence of glioma

increased astrocytoma incidence ( J:229481 )

• in left ventricle Ad-cre injected mice

increased oligodendroglioma incidence ( J:229481 )

• in left ventricle Ad-cre injected mice

nervous system

increased glioma incidence ( J:229481 )

• mice injected with an adenovirus expressing cre recombinase (Ad-Cre) into the left ventricle exhibit a 33.3% incidence of glioma

increased astrocytoma incidence ( J:229481 )

• in left ventricle Ad-cre injected mice

increased oligodendroglioma incidence ( J:229481 )

• in left ventricle Ad-cre injected mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
high grade glioma		DOID:3070	OMIM:PS137800	J:229481