Phenotypes Associated with This Genotype

Genotype
MGI:5791061

• Allelic Composition: Col1a1^M1Jrt/Col1a1⁺
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal locomotor behavior ( J:228439 )

• mice exhibit substantial limping

decreased vertical activity ( J:228439 )

• mice show decreased rearing attempts

decreased locomotor activity ( J:228439 )

• mice travel less distance in the open field glass chamber compared to wild-type mice

• overall counts of rotations in a home cage running wheel for one hour are reduced

abnormal mechanical nociception ( J:228439 )

• mice show decreased paw withdrawal thresholds to mechanical stimulation indicating increased sensitivity to mechanical stimuli

decreased thermal nociceptive threshold ( J:228439 )

• mice show decreased withdrawal latency to heat stimuli indicating increased heat sensitivity

• mice show increased behavioral responses to acetone indicating increased sensitivity to cold stimuli

growth/size/body

decreased body weight ( J:228439 )

homeostasis/metabolism

abnormal bone healing ( J:228439 )

• improper healing of the femur at the hip joint

• hyperplastic callus formation of olecranon process

immune system

autoimmune arthritis ( J:228439 )

• arthritic knees

limbs/digits/tail

abnormal autopod morphology ( J:228439 )

• hindpaw bone deformities

abnormal olecranon morphology ( J:228439 )

• deformity and fracture of olecranon processes

• hyperplastic callus formation of olecranon process

short femur ( J:228439 )

skeleton

abnormal bone healing ( J:228439 )

• improper healing of the femur at the hip joint

• hyperplastic callus formation of olecranon process

autoimmune arthritis ( J:228439 )

• arthritic knees

abnormal olecranon morphology ( J:228439 )

• deformity and fracture of olecranon processes

• hyperplastic callus formation of olecranon process

decreased length of long bones ( J:228439 )

short femur ( J:228439 )

abnormal pelvic girdle bone morphology ( J:228439 )

• deformity of coxae

abnormal vertebral column morphology ( J:228439 )

• reduction in cervical intervertebral disc space

scoliosis ( J:228439 )

• scoliosis-like spine deformity

decreased bone volume ( J:228439 )

• decrease in bone volume/tissue volume

decreased compact bone thickness ( J:228439 )

• decrease in cortical thickness

decreased bone trabecula number ( J:228439 )

osteophytes ( J:228439 )

atlanto-occipital joint dislocation ( J:228439 )

• atlanto-occipital joint dislocation

fragile skeleton ( J:228439 )

• deformity and fracture of olecranon processes

• tarsal-metatarsal fracture

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
osteogenesis imperfecta type 4		DOID:0110340	OMIM:166220	J:228439