Phenotypes Associated with This Genotype

Genotype
MGI:5792147

• Allelic Composition: Cdkn2a^tm4Rdp/Cdkn2a^tm4Rdp; Nf1^tm1Par/Nf1^tm1Par
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased sarcoma incidence ( J:234760 )

• mice injected intramuscularly with an adenovirus expressing cre recombinase (Ad-Cre) develop soft-tissue sarcomas in the region 3 to 12 months after cre exposure

• intramuscular injections of Ad-cre generates a spectrum of high-grade spindle cell sarcomas, including rhabdomyosarcoma and undifferentiated pleomorphic sarcoma

• tumors from both intramuscular and sciatic nerve Ad-Cre injected mice show significant infiltration of mast cells

• tumors arising from intramuscular Ad-Cre injection show higher proliferation than tumors arising from sciatic nerve Ad-Cre injection

• treatment of tumor cells isolated from intramuscularly Ad-Cre injected mice with the MEK inhibitor PD325901results in decreases colony-forming units and cell proliferation

• treatment of Ad-Cre intramuscularly injected mice with the MEK inhibitor PD325901 delays tumor growth, reduces proliferative index of tumors, and decreases CD31+ microvessel density but does not alter mast cell levels in tumors

increased rhabdomyosarcoma incidence ( J:234760 )

• intramuscularly Ad-Cre injected mice develop rhabdomyosarcoma

increased neurofibrosarcoma incidence ( J:234760 )

• mice injected with Ad-Cre in the sciatic nerve develop malignant peripheral nerve sheath tumors in the region at a mean time of 4.1 months after cre exposure

muscle

increased rhabdomyosarcoma incidence ( J:234760 )

• intramuscularly Ad-Cre injected mice develop rhabdomyosarcoma

nervous system

increased neurofibrosarcoma incidence ( J:234760 )

• mice injected with Ad-Cre in the sciatic nerve develop malignant peripheral nerve sheath tumors in the region at a mean time of 4.1 months after cre exposure

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
sarcoma		DOID:1115		J:234760