Analysis Tools
behavior/neurological
 N |
• mice exhibit normal simple spatial learning, repetitive grooming or social interaction
|
|
|
• mice exhibit ADHD-like behavior, including impaired attention performance with a visual distractor during anticipation
• however, mice exhibit normal sensorimotor performance and treatment with 1-EBIO mitigates distractibility
|
|
|
• profound unaffected by 1-EBIO treatment
|
|
|
• deficits in fear-induced freezing
|
|
|
• deficits in fear-induced freezing
|
|
|
• hyper-aggression that is unaffected by 1-EBIO treatment
|
|
|
• in an open field
• insensitive to amphetamine treatment
• however, treatment with 1-EBIO rescues hyperactivity
|
|
|
• highly fragmented sleep
|
nervous system
|
N |
• thalamic reticular nucleus (TRN) neurons exhibit normal resting membrane potential, input resistance and escape from hyperpolarization
|
|
|
• under voltage clamp, TRN neurons exhibit reduced SK currents and a 2-fold reduction of resting state intracellular calcium compared with wild-type cells
• TRN neurons exhibit reduced burst firing in sleep, an overall reduction in sleep spindle count and overall diminished engagement in spindle events compared with wild-type cells
• reduced visual-evoked inhibitory transients compared with wild-type cells
• in response to trains of stimuli, TRN neurons exhibit impaired inhibition without an augmentation as a result of repeated stimulation compared with wild-type cells
• however, T currents are normal and acute injection of the SK positive allosteric modulator 1-ethyl-benzimidazolinone (1-EBIO) mitigates impaired sensory-evoked thalamic inhibition
|
muscle
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| attention deficit hyperactivity disorder | DOID:1094 |
OMIM:143465 OMIM:608903 OMIM:608904 OMIM:608905 OMIM:608906 OMIM:612311 OMIM:612312 |
J:232709 | |
