Phenotypes Associated with This Genotype

Genotype
MGI:5792957

• Allelic Composition: Tg(Alb1-Myc)#Sst/0; Tg(MtTGFA)Lmb/0
• Genetic Background: involves: C57BL/6 * CBA * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased hepatocellular carcinoma incidence ( J:176432 )

♂ • hepatocarcinogenesis progresses from early (3 weeks) and severe hepatocyte dysplasia (3 months) to preneoplastic focal lesions and hepatocellular carcinoma within 4 months

♂ • by 9 months, more than 90% of mice develop hepatocellular carcinoma

hematopoietic system

decreased NK cell number ( J:176432 )

♂ • the relative contribution of hepatic natural killer (Cd49b+CD3-) and natural killer T (Cd49b+CD3+) cells is altered with the proportion of NK cells reduced and proportion of NKT cells increased in dysplastic livers

increased NK T cell number ( J:176432 )

♂ • the relative contribution of hepatic natural killer (Cd49b+CD3-) and natural killer T (Cd49b+CD3+) cells is altered with the proportion of NK cells reduced and proportion of NKT cells increased in dysplastic livers

immune system

decreased NK cell number ( J:176432 )

♂ • the relative contribution of hepatic natural killer (Cd49b+CD3-) and natural killer T (Cd49b+CD3+) cells is altered with the proportion of NK cells reduced and proportion of NKT cells increased in dysplastic livers

increased NK T cell number ( J:176432 )

♂ • the relative contribution of hepatic natural killer (Cd49b+CD3-) and natural killer T (Cd49b+CD3+) cells is altered with the proportion of NK cells reduced and proportion of NKT cells increased in dysplastic livers

liver/biliary system

increased hepatocellular carcinoma incidence ( J:176432 )

♂ • hepatocarcinogenesis progresses from early (3 weeks) and severe hepatocyte dysplasia (3 months) to preneoplastic focal lesions and hepatocellular carcinoma within 4 months

♂ • by 9 months, more than 90% of mice develop hepatocellular carcinoma

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:176432