Phenotypes Associated with This Genotype

Genotype
MGI:5795582

• Allelic Composition: Psen1^tm1Tak/Psen1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal brain morphology ( J:108326 )

• mice show increased levels of amyloid beta(1-42) peptide, however amyloid beta fails to deposit in the brains

neurofibrillary tangles ( J:108326 )

• some hippocampal neurons exhibit Congo red birefringence and Thioflavin T reactivity, indicating neurofibrillary tangles

tau protein deposits ( J:108326 )

• mice exhibit formation of tau inclusions starting at 7 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease 3		DOID:0110042	OMIM:607822	J:108326