Phenotypes Associated with This Genotype

Genotype
MGI:5796026

cn2

• Allelic Composition: Prkar1a^tm1.2Lsk/Prkar1a⁺; Tg(Bglap2-TAg)1Rkho/0; Tg(Col1a1-cre)1Kry/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Prkar1a heterozygosity accelerates osteosarcoma development in Tg(Bglap2-TAg)1Rkho/0 mice

mortality/aging

premature death ( J:165282 )

• no mice survive past 5 weeks of age

neoplasm

increased osteosarcoma incidence ( J:165282 )

• mice develop advanced osteosarcoma, often in the spine

• mice exhibit multi-ostotic tumors in long and flat bones, including the skull, vertebrae, ribs, and tibia

• however, metastasis is not seen at this early age

• tumors show increased osteoclast numbers

skeleton

increased osteosarcoma incidence ( J:165282 )

• mice develop advanced osteosarcoma, often in the spine

• mice exhibit multi-ostotic tumors in long and flat bones, including the skull, vertebrae, ribs, and tibia

• however, metastasis is not seen at this early age

• tumors show increased osteoclast numbers

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:165282 )

• impaired mobility due to osteosarcoma in the spine

paralysis ( J:165282 )

• paralysis due to osteosarcoma in the spine