Phenotypes Associated with This Genotype

Genotype
MGI:5796036

• Allelic Composition: Tg(Bglap2-TAg)1Rkho/0
• Genetic Background: FVB/N-Tg(Bglap2-TAg)1Rkho

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Poorly calcified femur tumor with bone destruction in a Tg(Bglap2-TAg)1Rkho/0 mouse

mortality/aging

decreased tumor-free survival time ( J:165282 )

• mice die after 21 weeks of age due to tumors

neoplasm

increased metastatic potential ( J:165282 )

• spontaneous metastases are seen in the lungs of more than 90% of mice at time of morbidity, and less frequently in the liver and occasionally in the kidney and spleen

increased skeletal tumor incidence ( J:165282 )

• mice form multi-ostotic bone tumors with complete penetrance at a young age and showing varying levels of calcification

• skeletal tumors show a peak incidence in the long bones and a higher prevalence of craniofacial tumors

• tumors exhibit increased osteoclast numbers

increased osteosarcoma incidence ( J:165282 )

• mice develop a spectrum of osteoblastic lesions from benign osteoma to aggressive metastatic osteosarcoma, with most being osteoblastic osteosarcoma, with features typical of high-grade osteosarcoma

• osteosarcomas are genomically unstable

skeleton

increased skeletal tumor incidence ( J:165282 )

• mice form multi-ostotic bone tumors with complete penetrance at a young age and showing varying levels of calcification

• skeletal tumors show a peak incidence in the long bones and a higher prevalence of craniofacial tumors

• tumors exhibit increased osteoclast numbers

increased osteosarcoma incidence ( J:165282 )

• mice develop a spectrum of osteoblastic lesions from benign osteoma to aggressive metastatic osteosarcoma, with most being osteoblastic osteosarcoma, with features typical of high-grade osteosarcoma

• osteosarcomas are genomically unstable

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
osteosarcoma		DOID:3347	OMIM:259500	J:165282