Phenotypes Associated with This Genotype

Genotype
MGI:5796166

• Allelic Composition: Prkar1a^tm1.2Lsk/Prkar1a⁺; Rb1^tm2Brn/Rb1⁺; Tg(Col1a1-cre)1Kry/0; Trp53^tm1Brn/Trp53^tm1Brn
• Genetic Background: involves: 129 * 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:234128 )

• mice survive to around 13.9 weeks

• treatment of mice with RANK-Fc prolongs survival to around 17.8 weeks

neoplasm

increased osteosarcoma incidence ( J:234128 )

• mice develop osteosarcoma within 10.3 weeks of age

• tumors are marked by high TNFSF11 (RANKL)/low TNFRSF11A (RANK) levels

• treatment of mice with RANK-Fc for 52 weeks beginning at 12.6 weeks of age keeps mice tumor-free until 64.6 weeks of age

skeleton

increased osteosarcoma incidence ( J:234128 )

• mice develop osteosarcoma within 10.3 weeks of age

• tumors are marked by high TNFSF11 (RANKL)/low TNFRSF11A (RANK) levels

• treatment of mice with RANK-Fc for 52 weeks beginning at 12.6 weeks of age keeps mice tumor-free until 64.6 weeks of age

cellular

increased cell migration ( J:234128 )

• in a scratch wound healing assay, tumor cells show greater migration than tumor cells from conditional Rb1^tm2Brn heterozygous Trp53^tm1Brn homozygous double mutants

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
osteosarcoma		DOID:3347	OMIM:259500	J:234128