Phenotypes Associated with This Genotype

Genotype
MGI:5796560

• Allelic Composition: Tg(MMTV-Erbb2)1Pv/0
• Genetic Background: involves: BALB/c * C57BL/6 * CD-1 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:234420 )

♀ • at 5-7 weeks of age, about 30% of mice exhibit mammary gland hyperplasia, from 8-13 weeks of age, 41% of mammary glands show atypical hyperplasia, features of carcinoma in situ are first seen at 14 weeks (9%) and progressively increase to 15% at 22-28 weeks, and invasive breast cancer (ductal breast adenocarcinoma) appears from week 22 and occupies 30% of the mammary glands

♀ • microvessel density markedly increase with mammary gland tumor progression from simple to atypical hyperplasia

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:234420 )

♀ • at 5-7 weeks of age, about 30% of mice exhibit mammary gland hyperplasia, from 8-13 weeks of age, 41% of mammary glands show atypical hyperplasia, features of carcinoma in situ are first seen at 14 weeks (9%) and progressively increase to 15% at 22-28 weeks, and invasive breast cancer (ductal breast adenocarcinoma) appears from week 22 and occupies 30% of the mammary glands

♀ • microvessel density markedly increase with mammary gland tumor progression from simple to atypical hyperplasia

integument

increased mammary adenocarcinoma incidence ( J:234420 )

♀ • at 5-7 weeks of age, about 30% of mice exhibit mammary gland hyperplasia, from 8-13 weeks of age, 41% of mammary glands show atypical hyperplasia, features of carcinoma in situ are first seen at 14 weeks (9%) and progressively increase to 15% at 22-28 weeks, and invasive breast cancer (ductal breast adenocarcinoma) appears from week 22 and occupies 30% of the mammary glands

♀ • microvessel density markedly increase with mammary gland tumor progression from simple to atypical hyperplasia

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:234420