Phenotypes Associated with This Genotype

Genotype
MGI:5800565

• Allelic Composition: Dnm1^Ftfl/Dnm1^tm1.2Frk
• Genetic Background: involves: 129 * C57BL/6J * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:235711 )

• due to lethal seizures

nervous system

seizures ( J:235711 )

• lethal maximal seizures with earlier onset (6 to 7 weeks) and increased severity compared with with Dnm1^Ftfl heterozygotes (11 to 12 weeks)

• reduced electroconvulsive threshold compared with Dnm1^Ftfl heterozygotes

abnormal brain wave pattern ( J:235711 )

• abnormal interictal EEG patterns with episodes of epileptiform spikes

behavior/neurological

seizures ( J:235711 )

• lethal maximal seizures with earlier onset (6 to 7 weeks) and increased severity compared with with Dnm1^Ftfl heterozygotes (11 to 12 weeks)

• reduced electroconvulsive threshold compared with Dnm1^Ftfl heterozygotes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
idiopathic generalized epilepsy		DOID:1827	OMIM:600669	J:235711