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Phenotypes Associated with This Genotype
Genotype
MGI:5803810
Allelic
Composition
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO/Prnp-APP*Swe*Lon)9191Krz/0
Genetic
Background
involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Camk2a-tTA)1Mmay mutation (8 available)
Tg(tetO/Prnp-APP*Swe*Lon)9191Krz mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Age-related amyloid beta plaque progression in Tg(tetO/Prnp-APP*Swe*Lon)9191Krz/0 Tg(Camk2a-tTA)1Mmay/0 mice

growth/size/body
• lower body weight in old mice

homeostasis/metabolism
• mice exhibit accumulation of amyloid beta plaques with age, first seen in the cerebral cortex at 8 months of age and then in the hippocampus between 10-12.5 months of age
• plaques include both dense-core and diffuse types and comparable plaque loads are seen in the cortex and hippocampus
• mice show an age-dependent increase in the production of amyloid beta 38, 40 and 42 in the brain, with more than 90% of amyloid beta 40 building the dense cores of plaques, and amyloid beta 42 being the main component of diffuse plaques and loosely core-associated oligomers

nervous system
• mice exhibit accumulation of amyloid beta plaques with age, first seen in the cerebral cortex at 8 months of age and then in the hippocampus between 10-12.5 months of age
• plaques include both dense-core and diffuse types and comparable plaque loads are seen in the cortex and hippocampus
• mice show an age-dependent increase in the production of amyloid beta 38, 40 and 42 in the brain, with more than 90% of amyloid beta 40 building the dense cores of plaques, and amyloid beta 42 being the main component of diffuse plaques and loosely core-associated oligomers
• mutants exhibit reduced forebrain weight compared to non-transgenic mice but similar in weight to single Tg(Camk2a-tTA)Mmay expressing mice
• mutants exhibit decreased dentate gyrus size compared to non-transgenic mice but size is similar to that seen in single Tg(Camk2a-tTA)Mmay expressing mice
• gliosis is associated with dense-core plaques
• mice exhibit aggravated axonal curvature and swollen, dystrophic neurites surrounding plaques

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Alzheimer's disease DOID:10652 J:235351


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory