Phenotypes Associated with This Genotype

Genotype
MGI:5803879

• Allelic Composition: Gas8^{Gt(CH0760)Wtsi}/Gas8^{Gt(CH0760)Wtsi}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:234173 )

• most mice die by P14 with few living mice at P21

growth/size/body

right-sided stomach ( J:234173 )

• in 6 of 16 live born mice

situs inversus with levocardia ( J:234173 )

• in 6 of 16 live born mice based on stomach and heart position

respiratory system

abnormal respiratory motile cilium physiology ( J:234173 )

• decreased beat frequency

abnormal tracheal ciliated epithelium morphology ( J:234173 )

• broken doublet rings and disorganized arrangement of microtubule doublets in some cilia with dyskinesia

• short cilia

nervous system

abnormal brain ependyma motile cilium physiology ( J:234173 )

• decreased beat frequency

hydrocephaly ( J:234173 )

• severe

cellular

abnormal brain ependyma motile cilium physiology ( J:234173 )

• decreased beat frequency

abnormal respiratory motile cilium physiology ( J:234173 )

• decreased beat frequency

digestive/alimentary system

right-sided stomach ( J:234173 )

• in 6 of 16 live born mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
primary ciliary dyskinesia 33		DOID:0110619	OMIM:616726	J:234173