Phenotypes Associated with This Genotype

Genotype
MGI:5804115

• Allelic Composition: Tg(Mafg-Nfe2l1)1Mym/0
• Genetic Background: involves: C57BL/6J * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:230118 )

• lower body weight than wild-type mice by 7 weeks of age when fed a regular diet

• mice fed a high-fat diet beginning at 6 weeks of age exhibit a lower body weight than high-fat diet fed wild-type mice

increased liver weight ( J:230118 )

• increase is liver tissue weight in mice fed a normal diet which is further enhanced on a high-fat diet

homeostasis/metabolism

abnormal blood homeostasis ( J:230118 )

• plasma beta-hydroxybutyrate levels of high fat diet fed mice is higher than in wild-type mice

decreased circulating ammonia level ( J:230118 )

• plasma ammonia levels are decreased in both normal diet and high fat diet fed mice

abnormal glucose homeostasis ( J:230118 )

• the liver of high-fat diet fed mice exhibits increased pyruvate, acetyl coenzyme A, citrate, and isocitrate levels and decreased lactate levels

hyperglycemia ( J:230118 )

• blood glucose level is increased in mice fed a normal diet

• mice fed a high-fat diet exhibit highly increased blood glucose levels compared to wild-type mice fed the same diet which show a mild increase in blood glucose levels

increased circulating insulin level ( J:230118 )

• plasma insulin level is increased in mice fed a normal diet

insulin resistance ( J:230118 )

• both normal diet and high-fat diet fed mice show higher blood glucose levels after insulin injection compared to wild-type mice, indicating insulin resistance

increased susceptibility to diet-induced non-insulin dependent diabetes ( J:230118 )

• mice fed a high-fat diet develop diabetes mellitus

endocrine/exocrine glands

abnormal pancreatic beta cell morphology ( J:230118 )

• the insulin-positive area in pancreatic sections is increased, suggesting constitutively activated insulin secretion

enlarged pancreatic islets ( J:230118 )

• islets are larger in mice fed a regular diet

liver/biliary system

increased liver weight ( J:230118 )

• increase is liver tissue weight in mice fed a normal diet which is further enhanced on a high-fat diet

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 2 diabetes mellitus		DOID:9352	OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036	J:230118