Phenotypes Associated with This Genotype

Genotype
MGI:5805260

cn1

• Allelic Composition: Yme1l1^tm1Tlan/Yme1l1^tm1Tlan; Tg(Ckmm-cre)5Khn/0
• Genetic Background: involves: C57BL/6 * C57BL/6NCrl * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating insulin level ( J:229455 )

• lowered fasting insulin levels in the serum

• however, mice exhibit normal fasting blood glucose, weight gains and body composition

impaired glucose tolerance ( J:229455 )

• glucose intolerance

cardiovascular system

cardiovascular system phenotype ( J:229455 )

N • mice show normal heart function and normal cardiac uptake of glucose smaller mitochondria in hearts

mortality/aging

mortality/aging ( J:229455 )

N • mice show a normal life span, with a median life span of 125 weeks