Phenotypes Associated with This Genotype

Genotype
MGI:5805456

• Allelic Composition: Tg(CD2-Rorc)#Staka/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal salivary gland physiology ( J:230700 )

• a few apoptotic cells are seen in the inflammatory lesions of salivary glands indicating destruction of salivary glands

decreased salivation ( J:230700 )

• amount of saliva collected from mutants is lower than from wild-type mice at 8 and 12 weeks of age, but not at 3 weeks

salivary gland inflammation ( J:230700 )

• mononuclear cells are seen infiltrating the salivary glands

• most infiltrating cells in the salivary gland are CD3+ T (mainly CD4+ T) cells and B cells gradually increase in number with age and most infiltrating cells at later states are B cells

nervous system

demyelination ( J:236222 )

• Theilers murine encephalomyelitis virus (TMEV) infected mice develop a demyelinating disease 2-3 months after infection that is not seen in infected wild-type mice

• viral antigen positive cells are seen around demyelinating lesions of TMEV-infected mice

immune system

salivary gland inflammation ( J:230700 )

• mononuclear cells are seen infiltrating the salivary glands

• most infiltrating cells in the salivary gland are CD3+ T (mainly CD4+ T) cells and B cells gradually increase in number with age and most infiltrating cells at later states are B cells

lacrimal gland inflammation ( J:230700 )

• mononuclear cells are seen infiltrating the lacrimal glands

decreased CD8-positive, alpha-beta T cell number ( J:236222 )

• mice have reduced CD8+ T cell numbers and enhanced IL-17 production during the acute phase of TMEV infection

• TMEV-infected mice show a decrease in the number of IFN-gamma secreting CD8+ T cells

abnormal CD4-positive, alpha beta T cell morphology ( J:236222 )

• TMEV-infected mice have a higher percentage of IL-17+ cells among CD4+ T cells at 1 week post infection

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:230700 )

• reduction in the number of CD4+CD25+Foxp3+ Treg cells in the thymus, spleen, and cervical lymph nodes

increased effector memory CD4-positive, alpha-beta T cell number ( J:230700 )

• CD4+ T cells in the spleen, cervical lymph nodes, and salivary glands are mainly effector memory cells

decreased IgG level ( J:236222 )

• mice infected with TMEV show slightly less anti-TMEV IgG responses than wild-type mice at 2 months post infection

decreased IgG2c level ( J:236222 )

• mice infected with TMEV have less anti-TMEV IgG2c in the serum than wild-type mice

decreased IgG3 level ( J:236222 )

• mice infected with TMEV have less anti-TMEV IgG3 in the serum than wild-type mice

abnormal T-helper 17 cell physiology ( J:236222 )

• mice have enhanced TMEV-specific Th17 immune responses during the chronic phase of TMEV infection

• TMEV-infected mice have enhanced Th17 immune responses in the CNS during the acute stage of infection

decreased interferon-gamma secretion ( J:236222 )

• isolated MNCs stimulated with TMEV produce less IFN-gamma than wild-type MNCs

increased interferon-gamma secretion ( J:236222 )

• spleen MNCs secrete more IFN-gamma at 1 week post TMEV infection than wild-type MNCs

• higher levels of IFN-gamma are seen in the spinal cord of TMEV-infected mice at 2 months post infection

decreased interleukin-10 secretion ( J:236222 )

• isolated MNCs stimulated with TMEV produce more less IL-10 than wild-type MNCs

increased interleukin-17 secretion ( J:236222 )

• isolated MNCs stimulated with TMEV produce more IL-17 than wild-type MNCs

• spleen MNCs secrete more IL-17 at 1 week post TMEV infection than wild-type MNCs

• spinal cords from TMEV-infected mice show higher levels of IL-17 at 2 months post infection

increased susceptibility to autoimmune disorder ( J:230700 )

• mice develop autoimmune sialadenitis-like Sjogrens Syndrome

• expression analysis of salivary gland lesions indicate the involvement of Th17, Th1, Th2, and Tfh cells in sialadenitis

increased autoantibody level ( J:230700 )

• mice show higher levels of anti-M3R and anti-Sjogrens syndrome type A (SSA) antibodies in sera and a trend toward increased anti-Sjogrens syndrome type B (SSB) antibodies

increased anti-nuclear antigen antibody level ( J:230700 )

• trend toward increased anti-ANA antibodies

lung inflammation ( J:230700 )

• mild mononuclear cell infiltration in lungs

abnormal susceptibility to Picornaviridae infection ( J:236222 )

• mice infected with the Daniels strain of Theilers murine encephalomyelitis virus (TMEV) develop an acute CNS disease similar to infected wild-type mice, showing similar incidence of seizures, and amounts of inflammation and neural death in the CNS, however they do not resolve the infection as in wild-type mice and develop Theilers murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD) with severe inflammatory demyelinating lesions in the spinal cord 2-3 months after infection

• inflammatory cells of TMEV-infected mice are primarily mononuclear cells (MNCs) and the majority of inflammatory cells in the spinal cord are CD3+

• TMEV-infected mice have more viral RNA in the CNS than wild-type mice at 1 week post infection

endocrine/exocrine glands

abnormal salivary gland physiology ( J:230700 )

• a few apoptotic cells are seen in the inflammatory lesions of salivary glands indicating destruction of salivary glands

decreased salivation ( J:230700 )

• amount of saliva collected from mutants is lower than from wild-type mice at 8 and 12 weeks of age, but not at 3 weeks

salivary gland inflammation ( J:230700 )

• mononuclear cells are seen infiltrating the salivary glands

• most infiltrating cells in the salivary gland are CD3+ T (mainly CD4+ T) cells and B cells gradually increase in number with age and most infiltrating cells at later states are B cells

lacrimal gland inflammation ( J:230700 )

• mononuclear cells are seen infiltrating the lacrimal glands

homeostasis/metabolism

decreased salivation ( J:230700 )

• amount of saliva collected from mutants is lower than from wild-type mice at 8 and 12 weeks of age, but not at 3 weeks

hematopoietic system

decreased CD8-positive, alpha-beta T cell number ( J:236222 )

• mice have reduced CD8+ T cell numbers and enhanced IL-17 production during the acute phase of TMEV infection

• TMEV-infected mice show a decrease in the number of IFN-gamma secreting CD8+ T cells

abnormal CD4-positive, alpha beta T cell morphology ( J:236222 )

• TMEV-infected mice have a higher percentage of IL-17+ cells among CD4+ T cells at 1 week post infection

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:230700 )

• reduction in the number of CD4+CD25+Foxp3+ Treg cells in the thymus, spleen, and cervical lymph nodes

increased effector memory CD4-positive, alpha-beta T cell number ( J:230700 )

• CD4+ T cells in the spleen, cervical lymph nodes, and salivary glands are mainly effector memory cells

decreased IgG level ( J:236222 )

• mice infected with TMEV show slightly less anti-TMEV IgG responses than wild-type mice at 2 months post infection

decreased IgG2c level ( J:236222 )

• mice infected with TMEV have less anti-TMEV IgG2c in the serum than wild-type mice

decreased IgG3 level ( J:236222 )

• mice infected with TMEV have less anti-TMEV IgG3 in the serum than wild-type mice

abnormal T-helper 17 cell physiology ( J:236222 )

• mice have enhanced TMEV-specific Th17 immune responses during the chronic phase of TMEV infection

• TMEV-infected mice have enhanced Th17 immune responses in the CNS during the acute stage of infection

respiratory system

lung inflammation ( J:230700 )

• mild mononuclear cell infiltration in lungs

behavior/neurological

behavior/neurological phenotype ( J:236222 )

N • although TMEV-infected mice develop inflammatory demyelination 2-3 months after infection, they do not show weight loss, waddling gait, or impaired righting reflex

vision/eye

lacrimal gland inflammation ( J:230700 )

• mononuclear cells are seen infiltrating the lacrimal glands

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Sjogren's syndrome		DOID:12894	OMIM:270150	J:230700