Phenotypes Associated with This Genotype

Genotype
MGI:5805519

• Allelic Composition: Tg(PyLT)1Vb/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal adrenal cortex morphology ( J:55528 )

• vacuolization of the cortical cell cytoplasm is seen in 4 month old adrenal glands, with vacuolization more apparent in females than males at this time

• cells of the cortex are vacuolated to varying degrees in the adrenals of 13-16 month old mice

thin adrenal cortex ( J:55528 )

• cortex thickness of the adrenal gland of 13-16 month old mice is reduced

increased adrenal gland weight ( J:55528 )

• mean weight of adrenal glands increases with age and is statistically significant at 9 and 12 months of age

adrenal medulla hyperplasia ( J:55528 )

• 1 of 3 females show minimal apparent medullary hyperplasia in the adrenal glands at 4 months of age

• adrenals of 13-16 month old mice show nodular hyperplasia of the medulla

enlarged adrenal glands ( J:55528 )

• size of adrenal gland is increased in 13-16 month old mice

increased pituitary gland tumor incidence ( J:55528 )

• neoplastic changes in pituitary are seen after 9 months of age and mice develop pituitary tumors with complete penetrance and a long latency with lifespan of about 14 months

increased pituitary adenoma incidence ( J:55528 )

• tumors resemble adenoma (groups and cords of tumor cells nestled around centrally located blood vessels)

growth/size/body

weight loss ( J:55528 )

• weight loss after 9 months of age for males and 12 months for females

increased body weight ( J:55528 )

• mice weigh more than controls at 9 months of age, but begin wasting at about 1 year of age

neoplasm

increased pituitary gland tumor incidence ( J:55528 )

• neoplastic changes in pituitary are seen after 9 months of age and mice develop pituitary tumors with complete penetrance and a long latency with lifespan of about 14 months

increased pituitary adenoma incidence ( J:55528 )

• tumors resemble adenoma (groups and cords of tumor cells nestled around centrally located blood vessels)

mortality/aging

premature death ( J:55528 )

• lifespan of about 14 months, with mean age of autopsy of 15.5 months for males and 13.1 months for females

behavior/neurological

ataxia ( J:55528 )

• mice develop an unsteady gait when they become clinically ill

homeostasis/metabolism

increased circulating adrenocorticotropin level ( J:55528 )

• mice show increased ACTH plasma levels

integument

abnormal hair growth ( J:55528 )

• clinically ill mice show loss of hair

nervous system

increased pituitary gland tumor incidence ( J:55528 )

• neoplastic changes in pituitary are seen after 9 months of age and mice develop pituitary tumors with complete penetrance and a long latency with lifespan of about 14 months

increased pituitary adenoma incidence ( J:55528 )

• tumors resemble adenoma (groups and cords of tumor cells nestled around centrally located blood vessels)

renal/urinary system

large penis ( J:55528 )

• enlarged penis

reproductive system

large penis ( J:55528 )

• enlarged penis

enlarged scrotum ( J:55528 )

• enlarged scrotal pads

skeleton

abnormal spine curvature ( J:55528 )

• mice develop a spinal hump in the thoracic region when they become clinically ill

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
ACTH-secreting pituitary adenoma		DOID:7004	OMIM:219090	J:55528