Phenotypes Associated with This Genotype

Genotype
MGI:5805976

• Allelic Composition: Tg(Cd4-NPM/ALK)N1Ingh/0
• Genetic Background: either: (involves: BALB/c * Swiss Webster) or (involves: C57BL/6 * Swiss Webster)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased plasmacytoma incidence ( J:82127 )

• plasmacytomas occurring in lymph nodes, spleen, and very rarely the thymus often completely replace these lymphoid organs and invade the surrounding tissues

increased hemolymphoid system tumor incidence ( J:82127 )

• 100% of mice develop spontaneous lymphoid tumors beginning at 5 weeks of age

• tumors are mainly thymic lymphomas or plasma cell neoplasms

increased lymphoblastic lymphoma incidence ( J:82127 )

• T cell tumors are exclusively lymphoblastic lymphomas

increased myeloma incidence ( J:82127 )

• greater than 80% prevalence of plasma cell tumors

• plasma cell tumors are of three types: tumors composed primary of mature plasma cells characterized by a large cytoplasm and eccentric and sometimes binucleated nuclei with evident nucleoli, tumors with large atypical cells with irregular nuclei and conscious nucleoli, and tumors with atypical, pleomorphic/anaplastic cells

• in 20% of mice, the neoplastic plasma cells occupy the bone marrow spaces and invade into the vertebral bones

• tumors are of B-cell origin and express clonal immunoglobulin

mortality/aging

premature death ( J:82127 )

• mean survival of 17 weeks

behavior/neurological

hindlimb paralysis ( J:82127 )

• mice that have neoplastic plasma cell invasion into vertebral bones and the central nervous system show frequent gross limb paralysis and other postural and behavioral habits

endocrine/exocrine glands

increased lymphoblastic lymphoma incidence ( J:82127 )

• T cell tumors are exclusively lymphoblastic lymphomas

hematopoietic system

increased lymphoblastic lymphoma incidence ( J:82127 )

• T cell tumors are exclusively lymphoblastic lymphomas

increased immunoglobulin level ( J:82127 )

• serum shows presence of free light chain immunoglobulin

immune system

increased lymphoblastic lymphoma incidence ( J:82127 )

• T cell tumors are exclusively lymphoblastic lymphomas

increased immunoglobulin level ( J:82127 )

• serum shows presence of free light chain immunoglobulin

nervous system

abnormal dorsal root ganglion morphology ( J:82127 )

• neoplastic plasma cells that invade into vertebral bones compress and often destroy the spinal ganglia

abnormal spinal nerve morphology ( J:82127 )

• neoplastic plasma cells that invade into vertebral bones compress and often destroy the spinal nerves

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
multiple myeloma		DOID:9538	OMIM:254500	J:82127